RT Journal Article
SR Electronic
T1 PHARMACOLOGICAL ESTIMATION OF DRUG-RECEPTOR DISSOCIATION CONSTANTS. STATISTICAL EVALUATION. II. COMPETITIVE ANTAGONISTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 13
OP 24
VO 177
IS 1
A1 WAUD, D. R.
A1 PARKER, R. B.
YR 1971
UL http://jpet.aspetjournals.org/content/177/1/13.abstract
AB A method is presented for objective statistical evaluation of the results of experiments designed to measure the dissociation constants of competitive antagonists by the method of Arunlakshana and Schild. The experimental dose-response data are fitted by the logistic function and a test of parallelism is included. Estimation of the dissociation constant from pairs of dose ratios and corresponding concentrations of antagonist is discussed. © 1971, by The Williams & Wilkins Company