RT Journal Article
SR Electronic
T1 EFFECTS OF NARCOTIC ANALGESICS UPON THE LOCOMOTOR ACTIVITY AND BRAIN CATECHOLAMINE CONTENT OF THE MOUSE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 472
OP 479
VO 176
IS 2
A1 C. R. RETHY
A1 C. B. SMITH
A1 J. E. VILLARREAL
YR 1971
UL http://jpet.aspetjournals.org/content/176/2/472.abstract
AB The relationship between the catecholamine-depleting and locomotor activity-increasing effects of morphine and related drugs was studied in the mouse. Morphine, levorphanol, l-methadone, ketobemidone and meperidine both increased locomotor activity and decreased brain catecholamine content. Thebaine and d-methadone did not alter either locomotor activity or brain catecholamine content. Tolerance developed to the effects of morphine and related analgesics upon both locomotor activity and brain catecholamine content after the repeated administration of either morphine or levorphanol. Pretreatment with naloxone prevented the effects of morphine and related analgesics upon both brain catecholamine content and locomotor activity. Neither tolerance to levorphanol nor pretreatment with naloxone altered the effects of d-amphetamine and dextrorphan upon locomotor activity and brain catecholamine content. © 1971 by The Williams & Wilkins Co.