PT  - JOURNAL ARTICLE
AU  - C. R. CRAIG
AU  - F. E. SHIDEMAN
TI  - METABOLISM AND ANTICONVULSANT PROPERTIES OF MEPHOBARBITAL AND PHENOBARBITAL IN RATS
DP  - 1971 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 35--41
VI  - 176
IP  - 1
4099  - http://jpet.aspetjournals.org/content/176/1/35.short
4100  - http://jpet.aspetjournals.org/content/176/1/35.full
SO  - J Pharmacol Exp Ther1971 Jan 01; 176
AB  - A gas chromatographic method for the simultaneous determination of both mephobarbital and phenobarbital in brain tissue has been described. It has been shown that after administration of a single dose of mephobarbital to rats the anticonvulsant response seen up to three hours can be ascribed to mephobarbital. At four hours and later a significant concentration of phenobarbital, the demethylated metabolic product of mephobarbital, was present in the brain and presumably contributed to the anticonvulsant activity. The extent to which phenobarbital contributes to the anticonvulsant activity of mephobarbital with long-term administration of the latter cannot be stated on the basis of these studies. © 1971, by The Williams & Wilkins Company