PT  - JOURNAL ARTICLE
AU  - PHILIP J. KADOWITZ
AU  - CHARLES S. SWEET
AU  - MICHAEL J. BRODY
TI  - POTENTIATION OF ADRENERGIC VENOMOTOR RESPONSES BY ANGIOTENSIN, PROSTAGLANDIN F<sub>2a</sub> AND COCAINE
DP  - 1971 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 167--173
VI  - 176
IP  - 1
4099  - http://jpet.aspetjournals.org/content/176/1/167.short
4100  - http://jpet.aspetjournals.org/content/176/1/167.full
SO  - J Pharmacol Exp Ther1971 Jan 01; 176
AB  - The influence of infusion of angiotensin, prostaglandin F2a, and cocaine on venoconstrictor responses to sympathetic nerve stimulation and norepinephrine was evaluated in the constant flow pump-perfused saphenous vein preparation of the dog. Infusion of angiotensin, 02 µ/min, increased mean arterial pressure but had no effect on saphenous vein perfusion pressure. Venoconstrictor responses to sympathetic nerve stimulation were enhanced, whereas responses to norepinephrine were not altered. Cocaine, 2 µg/min, and prostaglandin F2a 1 µg/min, had no effect on arterial pressure or saphenous vein perfusion pressure but markedly enhanced responses of the saphenous vein to both sympathetic nerve stimulation and injected norepinephrine. These studies indicate that angiotensin and prostaglandin F2a potentiate the response of the saphenous vein to sympathetic nerve stimulation by a different mechanism and suggest that both substances possess the capacity to act as modulators of adrenergic neurotransmission in venous smooth muscle. © 1971, by The Williams & Wilkins Company