RT Journal Article
SR Electronic
T1 THE METABOLISM OF CYCLAMATES IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 325
OP 330
VO 175
IS 2
A1 WALLACE, W. C.
A1 LETHCO, E. J.
A1 BROUWER, E. A.
YR 1970
UL http://jpet.aspetjournals.org/content/175/2/325.abstract
AB The metabolism of sodium and calcium cyclamate was studied in 63 rats after a p.o. intubation of C14-cyclamate to rats that had been fed cyclamates in the diet for a year or more. Essentially all of the administered dose was accounted for in the excreta after three days, with 35% appearing in the urine. The cyclamate was converted to cyclohexylamine in 83% of the rats; amounts ranged from less than 0.1 to 38%. Small quantities of cyclohexylamine were also found in the feces. No other metabolite was detectable. Although no attempt was made to determine at what stage during the feeding period the conversion of cyclamate to cyclohexylamine took place, prolonged or chronic feeding seemed to potentiate this conversion process. The bile is not an important route of excretion of cyclamate in the rat. © 1970 by The Williams & Wilkins Co.