PT  - JOURNAL ARTICLE
AU  - WALLACE, W. C.
AU  - LETHCO, E. J.
AU  - BROUWER, E. A.
TI  - THE METABOLISM OF CYCLAMATES IN RATS
DP  - 1970 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 325--330
VI  - 175
IP  - 2
4099  - http://jpet.aspetjournals.org/content/175/2/325.short
4100  - http://jpet.aspetjournals.org/content/175/2/325.full
SO  - J Pharmacol Exp Ther1970 Nov 01; 175
AB  - The metabolism of sodium and calcium cyclamate was studied in 63 rats after a p.o. intubation of C14-cyclamate to rats that had been fed cyclamates in the diet for a year or more. Essentially all of the administered dose was accounted for in the excreta after three days, with 35% appearing in the urine. The cyclamate was converted to cyclohexylamine in 83% of the rats; amounts ranged from less than 0.1 to 38%. Small quantities of cyclohexylamine were also found in the feces. No other metabolite was detectable. Although no attempt was made to determine at what stage during the feeding period the conversion of cyclamate to cyclohexylamine took place, prolonged or chronic feeding seemed to potentiate this conversion process. The bile is not an important route of excretion of cyclamate in the rat. © 1970 by The Williams & Wilkins Co.