PT  - JOURNAL ARTICLE
AU  - INGOGLIA, NICHOLAS A.
AU  - DOLE, VINCENT P.
TI  - LOCALIZATION OF <em>d</em>-AND <em>l</em>-METHADONE AFTER INTRAVENTRICULAR INJECTION INTO RAT BRAINS
DP  - 1970 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 84--87
VI  - 175
IP  - 1
4099  - http://jpet.aspetjournals.org/content/175/1/84.short
4100  - http://jpet.aspetjournals.org/content/175/1/84.full
SO  - J Pharmacol Exp Ther1970 Oct 01; 175
AB  - Stereotaxic injections of 10 µg of either d- or l-methadone, into a lateral cerebral ventricle of rats, produced analgesia only in those animals injected with the pharmacologically active l-isomer of methadone. The intraventricular injection of C14-labeled d- or l-methadone with H3-mannitol as an inert marker resulted in the accumulation of both d- and l-methadone in the region of the anterior hypothalamus before and during the period of maximal analgesia. There was no significant difference in the accumulation of the two isomers. Sagittal sectioning of the anterior hypothalamus showed no significant difference in the rates of diffusion of the two isomers of methadone, although the greater diffusabiity of mannitol laterally from the third ventricle compared to methadone could be demonstrated. © 1970, by The Williams & Wilkins Company