PT  - JOURNAL ARTICLE
AU  - PALMER, KEITH H.
AU  - FOWLER, MARY S.
AU  - WALL, MONROE E.
TI  - METABOLISM OF OPTICALLY ACTIVE BARBITURATES. II. S(-)-PENTOBARBITAL
DP  - 1970 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 38--41
VI  - 175
IP  - 1
4099  - http://jpet.aspetjournals.org/content/175/1/38.short
4100  - http://jpet.aspetjournals.org/content/175/1/38.full
SO  - J Pharmacol Exp Ther1970 Oct 01; 175
AB  - The urine from dogs which had received S(-)-pentobarbital yielded two crystalline metabolites from fractions obtained by partition column chromatography. The structures of the two major metabolites were found to be 5-ethyl-5-[3'-(S)-hydroxy-1'(S) methylbutyl] and 5-ethyl-5-[3'(R)-hydroxy-1'(S) methylbutyl] barbituric acids with the latter compound present in larger amounts. The significance of the larger amounts of the latter metabolite present in relation to the conformation of S(-)-and R(+)-pentobarbitals is discussed. © 1970, by The Williams & Wilkins Company