RT Journal Article
SR Electronic
T1 ON THE MEASUREMENT OF THE AFFINITY OF PARTIAL AGONISTS FOR RECEPTORS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 117
OP 122
VO 170
IS 1
A1 D. R. WAUD
YR 1969
UL http://jpet.aspetjournals.org/content/170/1/117.abstract
AB The dissociation constants for the drug-receptor reaction between muscarinic receptors and piocarpine or n-C7H15N†(CH3)3, have been measured in the smooth muscle of guinea-pig ileum. The measurements were obtained from a comparison of the dose-response curves to these partial agonists with the doseresponse curve to a strong agonist, carbachol. The results were compared with those obtained with the use of an irreversible competitive blocking agent. Both approaches gave similar values. © 1969, by The Williams & Wilkins Company