PT  - JOURNAL ARTICLE
AU  - D. R. WAUD
TI  - ON THE MEASUREMENT OF THE AFFINITY OF PARTIAL AGONISTS FOR RECEPTORS
DP  - 1969 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 117--122
VI  - 170
IP  - 1
4099  - http://jpet.aspetjournals.org/content/170/1/117.short
4100  - http://jpet.aspetjournals.org/content/170/1/117.full
SO  - J Pharmacol Exp Ther1969 Nov 01; 170
AB  - The dissociation constants for the drug-receptor reaction between muscarinic receptors and piocarpine or n-C7H15N†(CH3)3, have been measured in the smooth muscle of guinea-pig ileum. The measurements were obtained from a comparison of the dose-response curves to these partial agonists with the doseresponse curve to a strong agonist, carbachol. The results were compared with those obtained with the use of an irreversible competitive blocking agent. Both approaches gave similar values. © 1969, by The Williams & Wilkins Company