RT Journal Article
SR Electronic
T1 TRANS-SYNAPTIC INDUCTION OF ADRENAL TYROSINE HYDROXYLASE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 249
OP 254
VO 169
IS 2
A1 H. THOENEN
A1 R. A. MUELLER
A1 J. AXELROD
YR 1969
UL http://jpet.aspetjournals.org/content/169/2/249.abstract
AB Pretreatment of rats with 6-hydroxydopamine, reserpine and phenoxybenzamine, drugs which interfere with postganglionic sympathetic transmission by different mechanisms, induces an increase in the in vitro adrenal tyrosine hydroxylase activity. This increase in the rate-limiting enzyme in catecholamine synthesis can be prevented by interruption of the splanchnic nerves supplying the adrenal glands, whereas an elevation of the enzyme activity is still present in hypophysectomised animals. Adrenal denervation also partially prevents the depletion of catecholamines caused by reserpine and phenoxybenzamine. It is concluded that the elevation of tyrosine hydroxylase is mediated by a prolonged reflex increase in the splanchnic nerve activity as a consequence of drug-induced impairment of postganglionic sympathetic transmission. © 1969, by The Williams & Wilkins Co.