PT  - JOURNAL ARTICLE
AU  - NGUYEN B. THOA
AU  - DONALD ECCLESTON
AU  - JULIUS AXELROD
TI  - THE ACCUMULATION OF C-SEROTONIN IN THE GUINEA-PIG VAS DEFERENS
DP  - 1969 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 68--73
VI  - 169
IP  - 1
4099  - http://jpet.aspetjournals.org/content/169/1/68.short
4100  - http://jpet.aspetjournals.org/content/169/1/68.full
SO  - J Pharmacol Exp Ther1969 Sep 01; 169
AB  - C14-serotonin can be taken up by guinea-pig vas deferens tissue after an incubation in vitro. The accumulation is temperature-dependent and saturable and is blocked by cocaine, imipramine and ouabain, drugs known to interfere with the active transport of norepinephrine into the nerve cells, as well as by norepinephrine itself. The indoleamine appears to accumulate in the same intraneuronal sites which store endogenous norepinephrine. About half of the accumulated C14-serotonin is slowly released from the vas deferens within two hours. This release is enhanced by drugs which release norepinephrine, such as reserpine, tyramine, dopamine and norepinephrine. These observations suggest that uptake and storage in the sympathetic nerve terminals of peripheral tissues may not be specific processes for norepinephrine only, but for other normally occurring amines as well. © 1969, by The Williams & Wilkins Company