PT  - JOURNAL ARTICLE
AU  - A. E. TAKEMORI
AU  - HARVEY J. KUPFERBERG
AU  - JACK W. MILLER
TI  - QUANTITATIVE STUDIES OF THE ANTAGONISM OF MORPHINE BY NALORPHINE AND NALOXONE
DP  - 1969 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 39--45
VI  - 169
IP  - 1
4099  - http://jpet.aspetjournals.org/content/169/1/39.short
4100  - http://jpet.aspetjournals.org/content/169/1/39.full
SO  - J Pharmacol Exp Ther1969 Sep 01; 169
AB  - The in vivo equivalents of pA2 values for morphine-naloxone for antagonism of analgesia and intestinal inhibition in mice were 7.01 and 6.60, respectively. Although the estimation of a "pA2" for morphine-nalorphine was complicated by the latter's agonistic activity, the extrapolated value in the analgesic assay was 6.71. This value was different from a "pA3" of 5.63 obtained for antagonism of intestinal inhibition. © 1969, by The Williams & Wilkins Company