TY - JOUR T1 - QUANTITATIVE STUDIES OF THE ANTAGONISM OF MORPHINE BY NALORPHINE AND NALOXONE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 39 LP - 45 VL - 169 IS - 1 AU - A. E. TAKEMORI AU - HARVEY J. KUPFERBERG AU - JACK W. MILLER Y1 - 1969/09/01 UR - http://jpet.aspetjournals.org/content/169/1/39.abstract N2 - The in vivo equivalents of pA2 values for morphine-naloxone for antagonism of analgesia and intestinal inhibition in mice were 7.01 and 6.60, respectively. Although the estimation of a "pA2" for morphine-nalorphine was complicated by the latter's agonistic activity, the extrapolated value in the analgesic assay was 6.71. This value was different from a "pA3" of 5.63 obtained for antagonism of intestinal inhibition. © 1969, by The Williams & Wilkins Company ER -