RT Journal Article SR Electronic T1 LYSERGIC ACID DIETHYLAMIDE INTAKE IN PREGNANCY: FETAL DAMAGE IN RATS JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 48 OP 59 VO 173 IS 1 A1 GEORGE J. ALEXANDER A1 GEORGE M. GOLD A1 BRUNO E. MILES A1 RITA B. ALEXANDER YR 1970 UL http://jpet.aspetjournals.org/content/173/1/48.abstract AB Oral or subcutaneous administration of lysergic acid diethylamide (LSD) to hundreds of pregnant Wistar-O‘Grady rats resulted in damage to litters which was 3 to 4 times higher than in corresponding controls given distilled water or saline. The proportion of deaths during gestation, abortions, resorptions, runting, offspring stillbirths and the rate of offspring mortality was increased. However, no unusual number of specific deformities was encountered. Teratogenicity during any particular organogenetic period was not demonstrated. Treatment during the first seven days was found harmful; treatment later in pregnancy was ineffective. The LSD effects appear to be dose-related and persist into the second generation. © 1970, by The Williams & Wilkins Company