RT Journal Article
SR Electronic
T1 LYSERGIC ACID DIETHYLAMIDE INTAKE IN PREGNANCY: FETAL DAMAGE IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 48
OP 59
VO 173
IS 1
A1 ALEXANDER, GEORGE J.
A1 GOLD, GEORGE M.
A1 MILES, BRUNO E.
A1 ALEXANDER, RITA B.
YR 1970
UL http://jpet.aspetjournals.org/content/173/1/48.abstract
AB Oral or subcutaneous administration of lysergic acid diethylamide (LSD) to hundreds of pregnant Wistar-O‘Grady rats resulted in damage to litters which was 3 to 4 times higher than in corresponding controls given distilled water or saline. The proportion of deaths during gestation, abortions, resorptions, runting, offspring stillbirths and the rate of offspring mortality was increased. However, no unusual number of specific deformities was encountered. Teratogenicity during any particular organogenetic period was not demonstrated. Treatment during the first seven days was found harmful; treatment later in pregnancy was ineffective. The LSD effects appear to be dose-related and persist into the second generation. © 1970, by The Williams & Wilkins Company