PT  - JOURNAL ARTICLE
AU  - ALEXANDER, GEORGE J.
AU  - GOLD, GEORGE M.
AU  - MILES, BRUNO E.
AU  - ALEXANDER, RITA B.
TI  - LYSERGIC ACID DIETHYLAMIDE INTAKE IN PREGNANCY: FETAL DAMAGE IN RATS
DP  - 1970 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 48--59
VI  - 173
IP  - 1
4099  - http://jpet.aspetjournals.org/content/173/1/48.short
4100  - http://jpet.aspetjournals.org/content/173/1/48.full
SO  - J Pharmacol Exp Ther1970 May 01; 173
AB  - Oral or subcutaneous administration of lysergic acid diethylamide (LSD) to hundreds of pregnant Wistar-O‘Grady rats resulted in damage to litters which was 3 to 4 times higher than in corresponding controls given distilled water or saline. The proportion of deaths during gestation, abortions, resorptions, runting, offspring stillbirths and the rate of offspring mortality was increased. However, no unusual number of specific deformities was encountered. Teratogenicity during any particular organogenetic period was not demonstrated. Treatment during the first seven days was found harmful; treatment later in pregnancy was ineffective. The LSD effects appear to be dose-related and persist into the second generation. © 1970, by The Williams & Wilkins Company