TY - JOUR T1 - STRUCTURE-ACTIVITY RELATIONSHIPS OF N-ALKYL AND HETEROCYCLIC ANALOGS OF HEMICHOLINIUM-3 JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 315 LP - 321 VL - 168 IS - 2 AU - F. W. BENZ AU - J. P. LONG Y1 - 1969/08/01 UR - http://jpet.aspetjournals.org/content/168/2/315.abstract N2 - An extension of the series of analogs reported previously is presented. The fact that simple dimethylalkylammonium groups could maintain hemicholinium-3-like activity is demonstrated. The dimethylallyl derivative was the most active alkyl group studied, being one-half as active as hemicholinium-3. Maximum activity was expected for a group three carbons in length with one double bond (i.e., allyl group) since this grouping most resembles the 3-methyl-pyridinium system which was shown previously to be highly active. It was also shown that addition of a second methyl group to the 3-methylpyridinium system, regardless of position, decreased activity. From this it was concluded that the geometric aspects of the receptor for the 3-methylpyridinium analog are highly specific. © 1969 by The Williams & Wilkins Co. ER -