TY - JOUR T1 - THE ROLE OF CARBONIC ANHYDRASE IN ANION SECRETION INTO CEREBROSPINAL FLUID JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 197 LP - 202 VL - 172 IS - 2 AU - THOMAS H. MAREN AU - LAWRENCE E. BRODER Y1 - 1970/04/01 UR - http://jpet.aspetjournals.org/content/172/2/197.abstract N2 - The entry of total C14O2 and Cl36 from blood into cerebrospinal fluid (CSF) was studied in cats with ventriculo-cisternal perfusion both before and after the administration of acetazolamide, a carbonic anhydrase inhibitor. It was found that the normal animal accumulates total C14O2, by hydration of CO2 to HCO3-, at 5 times the rate of the inhibited animal, a difference that cannot be explained by changes in CSF production alone. The rate of entry of Cl36 in the normal animal was about twice that found in the inhibited animal, a change that was the same as that in CSF formation rate. It thus appears that both HCO3- formation and C1- transport into the CSF depend upon catalytic hydration of CO2, a process which may be important in the physiologic regulation of CSF acid-base equilibria and fluid production. © 1970, by The Williams & Wilkins Co. ER -