RT Journal Article
SR Electronic
T1 EFFECTS OF LITHIUM ON GANGLIONIC HYPERPOLARIZATION AND BLOCKADE BY DIMETHYLPHENYLPIPERAZINIUM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 166
OP 175
VO 164
IS 1
A1 JARAMILLO, JORGE
A1 VOLLE, ROBERT L.
YR 1968
UL http://jpet.aspetjournals.org/content/164/1/166.abstract
AB Ganglionic responses to dimethylphenylpiperazinium (DMPP) were modified in the following ways by ouabain (100 µg i.a.). The period of depolarization and associated early blockade of transmission were enhanced. The late occurring hyperpolanization was diminished, and the late occurring blockade of transmission was unaffected. Ganglionic depolarization and blockade by lobeline were intensified by ouabain. Perfusion of the ganglia with media containing lithium ions resulted in the abolition of DMPP-induced hyperpolarization but had no effect on the late occurring blockade of transmission. Conversely, perfusion of the ganglia with media at low temperature (22-25°C) had no effect on hyperpolarization by DMPP but prevented the appearance of the late occurring blockade. Collectively, the results indicate that the DMPP-induced hyperpolarization and late occurring blockade were temporally but not causally related events. © 1968, by The Williams & Wilkins Company