TY - JOUR T1 - ACYLPHENOTIAZINE ANTIINFLAMMATORY AGENTS WITH STEROID-LIKE ACTIVITY. I. 2-CHLORO-10-(β-DIMETHYL-AMINOPROPIONYL)-PHENOTHIAZINE-5-OXIDE HYDROCHLORIDE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 239 LP - 249 VL - 163 IS - 1 AU - ALFRED R. MAASS AU - GENEVIEVE SOSNOWSKI AU - VIRGIL D. WIEBELHAUS AU - JOSEPH WEINSTOCK Y1 - 1968/09/01 UR - http://jpet.aspetjournals.org/content/163/1/239.abstract N2 - SK& F 17910-A, (2-chloro-1O-(β-dimethylaminopropionyl)-pheno-thiazine-5-oxide hydrochloride), has antiinflammatory activity qualitatively and quantitatively similar to that produced by hydrocortisone. Oral antiinflammatory activity of SK& F 17910-A was 1ı5 to 03 times that of hydrocortisone in intact animals, using the pleural fluid, rat paw edema, carrageenan abscess and granuloma tests. SK& F 17910-A exhibited some thymolytic activity but did not cause adrenal atrophy or hyperplasia. In adrenolectomized (ADX) animals, SK& F 17910-A had a quantitatively similar antiinflammatory activity, clearly demonstrating that this activity was not the result of adrenal stimulation. Although SK& F 17910-A shares the antiiiiflammatory activity of hydrocortisone, it differs from hydrocortisone in having no effect upon glycogen deposition. But again, like hydrocortisone, SK& F 17910-A was inactive in the ultraviolet (UV) erythema test, a procedure which actively selects the known nonsteroidal antiinflammatory agents. In the water-unloading test in ADX rats, SK& F 17910-A and the glucocorticoids were unique in their ability to repair the defects in the excretion of a water load. Since other nonsteroidal antiinflammatory compounds were inactive in this procedure, it is concluded that SK& F 17910-A is a unique nonsteroidal antiinflammatory agent having some of the properties of the glucocorticoids. © 1968, by The Williams & Wilkins Company ER -