RT Journal Article
SR Electronic
T1 EFFECTS OF ANALGESICS AND OTHER DRUGS ON MICE IN PHENYLQUINONE AND ROTAROD TESTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 9
OP 13
VO 167
IS 1
A1 PEARL, JACK
A1 STANDER, HERBERT
A1 McKEAN, DONNA B.
YR 1969
UL http://jpet.aspetjournals.org/content/167/1/9.abstract
AB Fifteen minutes after s.c. injection, the narcotics (morphine and phenazocine) and the narcotic antagonists (nalorphine, levallorphan, l-cyclazocine and its cyclobutylmethyl homolog and l-pentazocine and its C-5 ethyl homolog) prevented phenylquinone-induced reactions at doses lower than those that affected rotarod performance. Pilocarpine also did so but produced salivation at about the same doses that prevented phenylquinone-induced reactions. d-Pentazocine, chlorpromazine and d-amphetamine did not prevent phenylquinone-induced reactions at doses lower than those that affected rotarod performance. Although the narcotic antagonists reached their peak activity in preventing phenylquinone-induced reactions within 15 min after injecton, the other drugs did not do so. © 1969, by The Williams & Wilkins Company