PT  - JOURNAL ARTICLE
AU  - PEARL, JACK
AU  - STANDER, HERBERT
AU  - McKEAN, DONNA B.
TI  - EFFECTS OF ANALGESICS AND OTHER DRUGS ON MICE IN PHENYLQUINONE AND ROTAROD TESTS
DP  - 1969 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 9--13
VI  - 167
IP  - 1
4099  - http://jpet.aspetjournals.org/content/167/1/9.short
4100  - http://jpet.aspetjournals.org/content/167/1/9.full
SO  - J Pharmacol Exp Ther1969 May 01; 167
AB  - Fifteen minutes after s.c. injection, the narcotics (morphine and phenazocine) and the narcotic antagonists (nalorphine, levallorphan, l-cyclazocine and its cyclobutylmethyl homolog and l-pentazocine and its C-5 ethyl homolog) prevented phenylquinone-induced reactions at doses lower than those that affected rotarod performance. Pilocarpine also did so but produced salivation at about the same doses that prevented phenylquinone-induced reactions. d-Pentazocine, chlorpromazine and d-amphetamine did not prevent phenylquinone-induced reactions at doses lower than those that affected rotarod performance. Although the narcotic antagonists reached their peak activity in preventing phenylquinone-induced reactions within 15 min after injecton, the other drugs did not do so. © 1969, by The Williams & Wilkins Company