PT  - JOURNAL ARTICLE
AU  - DE MELLO, W. C.
AU  - MOTTA, G. E.
TI  - THE EFFECT OF ALDOSTERONE ON MEMBRANE POTENTIAL OF CARDIAC MUSCLE FIBERS
DP  - 1969 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 166--172
VI  - 167
IP  - 1
4099  - http://jpet.aspetjournals.org/content/167/1/166.short
4100  - http://jpet.aspetjournals.org/content/167/1/166.full
SO  - J Pharmacol Exp Ther1969 May 01; 167
AB  - The effect of aldosterone on transmembrane potentials of cardiac muscle and pacemaker fibers of the rabbit heart was investigated. It was found that the hormone reduces the polarization of the heart cell membrane and decreases the excitability of atrial muscle. The depolarizing action of the hormone, which appears only after a prolonged exposure (50-60 min), was not observed at 15° C or at 10° C, which suggests that energy-consuming reactions are involved in the mechanism of depolarization. A decrease in heart rate and in the rate of repolarization of the action potentials was also observed. No antagonism between the hormone and acetyicholine on resting membrane potential of atrial muscle fibers was found. © 1969, by The Williams & Wilkins Company