PT  - JOURNAL ARTICLE
AU  - McPHILLIPS, JOSEPH J.
TI  - SUBSENSITIVITY OF THE RAT ILEUM TO CHOLINERGIC DRUGS
DP  - 1969 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 249--254
VI  - 166
IP  - 2
4099  - http://jpet.aspetjournals.org/content/166/2/249.short
4100  - http://jpet.aspetjournals.org/content/166/2/249.full
SO  - J Pharmacol Exp Ther1969 Apr 01; 166
AB  - Treatment of rats for 10 days with Di-Syston, an organophosphorus cholinesterase inhibitor, produced subsensitivity of the ileum to carbachol, oxotremorine and furtrethonium. The same treatment caused an increased sensitivity of the ileuin to acetylcholine and butyrylcholine which was not unexpected since both of these substances are hydrolyzed by ileum cholinesterase. Subsensitivity did not develop to the action of potassium or to the action of methacholine, a result which suggests that subsensitivity may develop only to certain types of drugs. © 1969 by The Williams & Wilkins Co.