RT Journal Article
SR Electronic
T1 INVESTIGATIONS ON A SERIES OF HETEROCYCLIC HEMICHOLINIUM-3 ANALOGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 225
OP 236
VO 166
IS 2
A1 BENZ, F. W.
A1 LONG, J. P.
YR 1969
UL http://jpet.aspetjournals.org/content/166/2/225.abstract
AB Eight substituted pyridinium and N-methylpiperidinium analogs of hemicholinium-3 were evaluated for their ability to block neuromuscular transmission in the rabbit and to inhibit human erythrocyte acetylcholinesterase. The 3-methylpyridinium and 4-methylpiperidinium derivatives were found to be equipotent to hemicholinium-3 as neuromuscular blockers. The low activity of the 3-methylpiperidinium analog is tentatively explained on the basis of enantiomeric dilution coupled with a possible low yield of the active conformer on quaternization. © 1969 by The Williams & Wilkins Co.