RT Journal Article
SR Electronic
T1 THE INFLUENCE OF THE SYMPATHETIC NERVOUS SYSTEM ON THE ACTION OF DRUGS ON THE LENS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 8
OP 13
VO 166
IS 1
A1 WEINSTOCK, MARTA
A1 MARSHALL, A. S.
YR 1969
UL http://jpet.aspetjournals.org/content/166/1/8.abstract
AB Morphine and related drugs produce reversible opacities in the lens of mice within 15 min of injection. This effect can be prevented by drugs which abolish sympathetic nerve activity in the eye and produce ptosis. These include phentolamine, phenoxybenzamine, guanethidine and reserpine. Antagonism by reserpine is evident within 15 min of its injection and lasts 24 hr. The lenticular effect is also prevented by cervical sympathectomy. The opacity results from prolonged lid retraction due to central stimulation of the sympathetic nervous system by analgesic drugs. The changes produced by lid retraction on the tonicity of the aqueous humor are discussed. The lens opacity produced by chlorpromazine and imipramine is not due to lid retraction but to an effect which results from the hypothermia they cause in mice. © 1969, by The Williams & Wilkins Company