TY - JOUR T1 - BRONCHOPULMONARY EFFECTS OF PENTAERYTHRITYL TETRANITRATE AND ISOPROTERENOL JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 274 LP - 285 VL - 165 IS - 2 AU - DOMINGO M. AVIADO AU - TAKETOSHI KISHIMOTO AU - HENRY J. KNEIDINGER Y1 - 1969/02/01 UR - http://jpet.aspetjournals.org/content/165/2/274.abstract N2 - The inhalation of pentaerythrityl tetranitrate (PETN) caused a significant reduction in pulmonary resistance in the anesthetized dog. The potency of PETN is one-third to one-fifth that of isoproterenol in producing an equivalent fall in pulmonary resistance. This effect of PETN was interpreted to indicate bronchodilatation and was accompanied by an inhibition of the cough reflex, fall in pulmonary arterial pressure, increase in pulmonary compliance and improvement in arterial blood oxygen tension. There were no significant changes in the heart rate and systemic blood pressure when minimal effective doses of PETN (11 to 112 , µg) were inhaled. © 1969 by The Williams & Wilkins Co. ER -