TY - JOUR T1 - ENZYMATIC CONVERSION OF NOREPINEPHRINE TO EPINEPHRINE BY THE BRAIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 190 LP - 195 VL - 165 IS - 2 AU - LARISSA A. POHORECKY AU - MICHAEL ZIGMOND AU - HARVEY KARTEN AU - RICHARD J. WURTMAN Y1 - 1969/02/01 UR - http://jpet.aspetjournals.org/content/165/2/190.abstract N2 - The epinephrine-forming enzyme phenylethanolamine-N-methyl transferase (PNMT) can be demonstrated in various brain regions of the rat, cat, hen and turtle. The activity of the enzyme is greatest when either norepinephrine or phenylethanolamine is used as its substrate in the olfactory tubercle and olfactory bulb. PNMT activity is elevated in the olfactory tubercle among rats treated with dexamethasone for 7 days. After the injection of H3-norepinephrine into the lateral cerebral ventricle, a large fraction of the amine is converted to H3-epinephrine and stored in the olfactory bulb. © 1969 by The Williams & Wilkins Co. ER -