TY - JOUR T1 - INHIBITION OF THE METABOLISM OF H3-MELATONIN BY PHENOTHIAZINES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 367 LP - 372 VL - 161 IS - 2 AU - Richard J. Wurtman AU - Julius Axelrod AU - Fernando Anton-Tay Y1 - 1968/06/01 UR - http://jpet.aspetjournals.org/content/161/2/367.abstract N2 - After rats are treated acutely with chlorpromazine, there is an elevation in the level of i.v. administered H3-melatonin in brain and blood. This effect is not the result of the hypothermia produced by chlorpromazine. Other phenothiazines, such as promazine and promethazine, also elevate tissue H3-melatonin. Chlorpromazine has no effect on the level of H3-melatonin when the indole is administered to rats by injection into the lateral cerebral ventricle. Chlorpromazine inhibits the in vitro metabolism of H3-melatonin by liver slices, suggesting that the drug alters the tissue levels of the indole by slowing its metabolism. Chronic treatment with phenobarbital causes a decreased H3-melatonin concentration in the brain 30 min after i.v. injection of the indole. © 1968 by The Williams & Wilkins Company ER -