@article {Bito302, author = {Laszlo Z. Bito and Paul Taylor and Jonathan Wyner}, title = {THE ABSENCE OF SYMPATHETIC ROLE IN ANTI-CHEINDUCED CHANGES IN CHOLINERGIC TRANSMISSION}, volume = {161}, number = {2}, pages = {302--309}, year = {1968}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The possibility was investigated that previously described changes in the pharmacologic behavior of the iris of the anti-ChE-treated eye are due to sympathetic inhibition of the sphincter muscle. Sympathetic influence was eliminated by sympathetic decentralization of one or both eyes prior to anti-ChE (anticholinesterase) treatment and/or by systemic administration of reserpine (cats) or chlorpromazine (cats and rabbits) or by intravitreal injection of guanethidine (rabbits) after prolonged treatment of the eyes with anti-ChE. Sympathetic decentralization of the eye did not prevent redilatation of the pupil during anti-ChE treatment. Sympathetic decentralization or the sympatholytic agents used did not inhibit light reflexes or reverse the anti-ChE-induced insensitivity of the iris to pilocarpine or carbachol. These results show that neither the sympathetic nervous system nor sympathetic neurotransmitters play a detectable role in anti-ChE-induced alterations in the pharmacologic behavior of the iris. it is concluded that, in the case of the iris, the site or sites of the anti-ChE-induced changes are the cholinergic receptors and/or the parasympathetic nerve terminals of the sphincter muscle. {\textcopyright} 1968 by The Williams \& Wilkins Company}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/161/2/302}, eprint = {https://jpet.aspetjournals.org/content/161/2/302.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }