PT  - JOURNAL ARTICLE
AU  - Efraín G. Pardo
AU  - Enrique Hong
AU  - Jacques Lelorier
TI  - AUTOINHIBITION IN RABBIT AORTIC STRIPS AFTER EPINEPHRINE
DP  - 1967 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 303--310
VI  - 157
IP  - 2
4099  - http://jpet.aspetjournals.org/content/157/2/303.short
4100  - http://jpet.aspetjournals.org/content/157/2/303.full
SO  - J Pharmacol Exp Ther1967 Aug 01; 157
AB  - Experiments have been carried out to characterize further the autoinhibitory phenomenon which follows contact of rabbit aortic strips with epinephrine. Desensitization was found to occur after exposure to very low concentrations of the catecholamines. The time course of recovery from inhibitory contacts with different concentrations of epinephrine was such as to predict that autoinhibition would generally he a significant factor in modifying experimental determinations of dose-response relationships. This was found to be the case, and a graphical method, leading to drug-effect hysteresis loops, is proposed as a means of assessing the degree of participation of this factor in a given experimental situation. © 1967 by The Williams & Wilkins Company