PT  - JOURNAL ARTICLE
AU  - L. Maitre
AU  - E. Wyss
TI  - MONOAMINE OXIDASE INHIBITING PROPERTIES OF SU-11,739 IN THE RAT. COMPARISON WITH PARGYLINE, TRANYLCYPROMINE AND IPRONIAZID
DP  - 1967 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 81--88
VI  - 157
IP  - 1
4099  - http://jpet.aspetjournals.org/content/157/1/81.short
4100  - http://jpet.aspetjournals.org/content/157/1/81.full
SO  - J Pharmacol Exp Ther1967 Jul 01; 157
AB  - N-methyl-N-2-propynyl-1-indanamine, is a new nonhydrazine monoamine oxidase (MAO) inhibitor. It is characterized by a very high potency in vitro as well as by a relatively selective lack of action on liver MAO in vivo. A single s.c. injection of 1.5 mg/kg of Su-11,739 caused significant MAO inhibition for at least 3 weeks in the brain while the liver recovered normal MAO activity after about 1 week. In vivo, Su-11,739 was found to be 15 to 25 times more potent than pargyline and to differ qualitatively from tranylcypromine and iproniazid, principally by its selectivity for MAO of the central nervous system. © 1967 by The Williams & Wilkins Company