PT  - JOURNAL ARTICLE
AU  - W. Levin
AU  - R. M. Welch
AU  - A. H. Conney
TI  - EFFECT OF PHENOBARBITAL AND OTHER DRUGS ON THE METABOLISM AND UTEROTROPIC ACTION OF ESTRADIOL-17β AND ESTRONE
DP  - 1968 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 362--371
VI  - 159
IP  - 2
4099  - http://jpet.aspetjournals.org/content/159/2/362.short
4100  - http://jpet.aspetjournals.org/content/159/2/362.full
SO  - J Pharmacol Exp Ther1968 Feb 01; 159
AB  - Treatment of immature female rats with phenobarbital for 4 days stimulates the activity of liver microsomal enzymes that metabolize estradiol-17β and estrone, inhibits the estradiol- or estrone-induced increases in uterine wet weight and decreases the amount of tritiated estrogen found in the uterus after an injection of tritiated estradiol or estrone. Treatment of rats with as little as 1 mg of phenobarbital per kg twice daily for 4 days causes a 37% inhibition in the uterotropic action of a 0.2-µg injection of tritiated estrone, and the concentration of radioactive steroid in the uterus is decreased. The metabolism of estradiol by liver microsomes in vitro is enhanced when the microsomes are harvested from animals pretreated with several unrelated microsomal enzyme inducers such as phenobarbital, chlordane, orphenadrine, chlorcyclizine, norchlorcyclizine and phenylbutazone. Pretreatment of rats with these chemicals also inhibits the action of estradiol on the uterus and decreases the concentration of estradiol in this organ. © 1968 by The Williams & Wilkins Company