PT  - JOURNAL ARTICLE
AU  - Arnold J. Wohl
AU  - Lorraine M. Hausler
AU  - Franklin E. Roth
TI  - STUDIES ON THE MECHANISM OF ANTIHYPERTENSIVE ACTION OF DIAZOXIDE: <em>IN VITRO</em> VASCULAR PHARMACODYNAMICS
DP  - 1967 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 531--539
VI  - 158
IP  - 3
4099  - http://jpet.aspetjournals.org/content/158/3/531.short
4100  - http://jpet.aspetjournals.org/content/158/3/531.full
SO  - J Pharmacol Exp Ther1967 Dec 01; 158
AB  - Diazoxide (7-chloro-3-methyl-2H-1 ,2,4-benzothiacliazine-1 , 1-dioxide), a nondiuretic benzothiadiazine antihypertensive agent, attenuates vascular responses to a variety of vasoconstrictor substances. An in vitro pharmacodynamic study was designed to specify the type or types of inhibition involved in this vascular action. The results indicate that diazoxide competes with barium for a specific receptor site in the vascular smooth muscle of the rat aorta. The location of this receptor is apparently closer to the process of muscle contraction than the alpha-adrenergic receptor, and may be a site normally activated by calcium. The specific competitive inhibition of barium-stimulated vasoconstriction by diazoxide may help to explain the mechanism by which diazoxide, and possibly other benzothiadiazine antihypertensive agents (e.g., chlorothiazide), reduces blood pressure. © 1967 by The Williams & Wilkins Company