PT  - JOURNAL ARTICLE
AU  - John L. Egle, Jr.
AU  - Jesse H. Meredith
AU  - J. Maxwell Little
TI  - THE EFFECT OF DICHLOROISOPROTERENOL, PRONETHALOL AND PROPRANOLOL ON OXYGEN CONSUMPTION IN THE RAT
DP  - 1967 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 399--404
VI  - 158
IP  - 3
4099  - http://jpet.aspetjournals.org/content/158/3/399.short
4100  - http://jpet.aspetjournals.org/content/158/3/399.full
SO  - J Pharmacol Exp Ther1967 Dec 01; 158
AB  - Certain beta-adrenergic blocking agents have been observed to increase the oxygen consumption of anesthetized dogs and to increase plasma free fatty acid levels. In this study, the effects of three beta-blocking drugs, dichloroisoproterenol (DCI), pronethalol and propranolol, on total-body oxygen consumption in the rat were examined. Both DCI and pronethalol were found to increase oxygen consumption in a doserelated manner. Propranolol did not increase oxygen consumption but instead lowered it in high doses. Propranolol was found to produce a partial antagonism of the oxygen consumption effects of DCI and pronethalol. Propranolol also afforded protection against lethal doses of DCI and pronethalol. It appears that DCI and pronethalol exert a beta-stimulatory action resulting in increased oxygen consumption. However, propranolol is antagonistic in regard to this response. © 1967 by The Williams & Wilkins Company