@article {Egle399, author = {John L. Egle, Jr. and Jesse H. Meredith and J. Maxwell Little}, title = {THE EFFECT OF DICHLOROISOPROTERENOL, PRONETHALOL AND PROPRANOLOL ON OXYGEN CONSUMPTION IN THE RAT}, volume = {158}, number = {3}, pages = {399--404}, year = {1967}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Certain beta-adrenergic blocking agents have been observed to increase the oxygen consumption of anesthetized dogs and to increase plasma free fatty acid levels. In this study, the effects of three beta-blocking drugs, dichloroisoproterenol (DCI), pronethalol and propranolol, on total-body oxygen consumption in the rat were examined. Both DCI and pronethalol were found to increase oxygen consumption in a doserelated manner. Propranolol did not increase oxygen consumption but instead lowered it in high doses. Propranolol was found to produce a partial antagonism of the oxygen consumption effects of DCI and pronethalol. Propranolol also afforded protection against lethal doses of DCI and pronethalol. It appears that DCI and pronethalol exert a beta-stimulatory action resulting in increased oxygen consumption. However, propranolol is antagonistic in regard to this response. {\textcopyright} 1967 by The Williams \& Wilkins Company}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/158/3/399}, eprint = {https://jpet.aspetjournals.org/content/158/3/399.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }