PT  - JOURNAL ARTICLE
AU  - H. Kalant
AU  - W. Grose
TI  - EFFECTS OF ETHANOL AND PENTOBARBITAL ON RELEASE OF ACETYLCHOLINE FROM CEREBRAL CORTEX SLICES
DP  - 1967 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 386--393
VI  - 158
IP  - 3
4099  - http://jpet.aspetjournals.org/content/158/3/386.short
4100  - http://jpet.aspetjournals.org/content/158/3/386.full
SO  - J Pharmacol Exp Ther1967 Dec 01; 158
AB  - Ethanol, 0.11 M, reduces reversibly the amount of acetylcholine released by slices of rat or guinea-pig cerebral cortex incubated in medium containing 5 mM K+; in 15 or 27 mM K+ the acetylcholine release is greater but ethanol has no detectable effect. Pentobarbital has a biphasic effect, low concentrations stimulating and high concentrations inhibiting acetylcholine release. Both the stimulatory and inhibitory effects of pentobarbital are increased by raising the K+ concentration of the medium. In 15 mM K+, ethanol has no effect by itself but enhances the stimulatory effect of 0.01 mM pentobarbital. Brain slices from animals made tolerant to ethanol, by daily administration of intoxicating doses, are refractory to the in vitro effect of ethanol on acetylcholine release. © 1967 by The Williams & Wilkins Company