RT Journal Article
SR Electronic
T1 PHARMACOLOGIC STUDIES OF NOREPINEPHRINE, ACETYLCHOLINE AND RELATED COMPOUNDS ON NEURONS IN DEITERS' NUCLEUS AND THE CEREBELLUM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 39
OP 47
VO 156
IS 1
A1 C. Yamamoto
YR 1967
UL http://jpet.aspetjournals.org/content/156/1/39.abstract
AB Using multibarreled electrodes, the effects of electrophoretically applied norepinephrine (NE) and acetylcholine (ACh) were studied on the lateral vestibular nucleus (NVL) neurons in cats. In contrast to most neurons in other parts of the mammalian brain, these neurons responded to NE with excitation so far as they were sensitive to the substance. This excitation was not blocked by N-(2-chloroethyl)-dibenzylamine hydrochloride or phentolamine, but was blocked by dichloroisopropylarterenol. Isopropylarterenol, however, had no effect upon NVL neurons. ACh also excited NVL neurons and this excitation was blocked by atropine. In the cerebellum, NE exerted excitatory effects upon neurons in the flocculus while it depressed the firing of cells in the neocerebellum. The possible physiologic roles of NE and ACh excitation are discussed. © 1967 by The Williams & Wilkins Company