RT Journal Article SR Electronic T1 THE EFFECT OF PHENYRAMIDOL ON THE METABOLISM OF BISHYDROXYCOUMARIN JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 660 OP 666 VO 154 IS 3 A1 Harvey M. Solomon A1 John J. Schrogie YR 1966 UL http://jpet.aspetjournals.org/content/154/3/660.abstract AB Phenyramidol inhibits the metabolism of bishydroxycoumarin in the mouse, rabbit and man and thus prolongs the pharmacologic effect of the anticoagulant. Phenyramidol (40 mg/kg) does not affect the metabolism of meperidine, aminopyrine, zoxazolamine, pentobarbital or sulfanilamide, although it potentiates the action of pentobarbital in the SW mouse. Evidence is presented to illustrate the role of genetic factors in the metabolism of bishydroxycoumarin and antipyrine in rabbits. The implications of such findings in drug evaluation and in clinical drug therapy are discussed © 1966 by The Williams & Wilkins Co.