PT  - JOURNAL ARTICLE
AU  - Rudolf P. Buhs
AU  - Donald Polin
AU  - John O. Beattie
AU  - John L. Beck
AU  - Jack L. Smith
AU  - Otto C. Speth
AU  - Nelson R. Trenner
TI  - THE METABOLISM OF ETHOPABATE IN CHICKENS
DP  - 1966 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 357--363
VI  - 154
IP  - 2
4099  - http://jpet.aspetjournals.org/content/154/2/357.short
4100  - http://jpet.aspetjournals.org/content/154/2/357.full
SO  - J Pharmacol Exp Ther1966 Nov 01; 154
AB  - The metabolism by the chicken of orally ingested ethopaabate has been studied, and over 98% of the drug consumed has been accounted for in the urine. Of the urinary excreted drug, about 80 to 85%, on the average, has been isolated and identified as the following metabolites: 20% as 2-ethoxy-4-acetamidobenzoic acid, 15% as 2-ethoxy-4-aminobenzoic acid, 25% as 2-ethoxy-4-amino-5-hythoxybenzoic acid-5-O-sulfate and about 25% as two individual fractions consisting of unidentified conjugates of one or the other of the above first two metabolites. All but the 5-hydroxylated metabolite and about 10% of unknown products are convertible to m-phenetidine, which is the basis of the convenient assay for ethopabate in biologic media. © 1966 by The Williams & Wilkins Company