PT  - JOURNAL ARTICLE
AU  - William D. Morain
AU  - Carol A. Replogle
AU  - Peter F. Curran
TI  - EFFECT OF DIMETHYL SULFOXIDE ON PERMEABILITY AND ELECTRICAL PROPERTIES OF FROG SKIN
DP  - 1966 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 298--302
VI  - 154
IP  - 2
4099  - http://jpet.aspetjournals.org/content/154/2/298.short
4100  - http://jpet.aspetjournals.org/content/154/2/298.full
SO  - J Pharmacol Exp Ther1966 Nov 01; 154
AB  - Dimethyl sulfoxide (DMSO) added to the external bathing solution of isolated frog skin causes a decrease in electrical potential difference and an increase in conductance but little change in short-circuit current. The permeability of the skin to mannitol, urea, sodium, potassium and chloride is increased by DMSO but the rate of net active Na transport is not changed markedly. The effects appear to be mainly the result of changes in osmotic activity of the bathing solution since they are similar to the effects caused by urea in similar concentrations. © 1966 by The Williams & Wilkins Company