TY - JOUR T1 - THE CARDIOPULMONARY EFFECTS OF QUINIDINE AND PROCAINAMIDE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 92 LP - 102 VL - 154 IS - 1 AU - Luis E. Folle AU - Domingo M. Aviado Y1 - 1966/10/01 UR - http://jpet.aspetjournals.org/content/154/1/92.abstract N2 - In the anesthetized dog, the intravenous injection of quinidine consistently induces a fall in systemic blood pressure hut a biphasic rise and fall in pulmonary arterial pressure. The femoral and pulmonary blood vessels are dilated but the heart is initially stimulated and depressed. All these effects are manifestations of local actions of quinidine on the heart and blood vessels, except the cardiac stimulation. Like quinidine, procainamide dilates the pulmonary and femoral blood vessels and depresses the heart. Unlike quinidine, procainamide induces a pure fall in pulmonary arterial pressure. © 1966 by The Williams & Wilkins Company ER -