RT Journal Article
SR Electronic
T1 ABSORPTION, DISTRIBUTION AND METABOLISM OF DIMETHYLSIJLFOXIDE IN THE RAT, RABBIT AND GUINEA PIG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 176
OP 184
VO 154
IS 1
A1 H. B. Hucker
A1 P. M. Ahmad
A1 E. A. Miller
YR 1966
UL http://jpet.aspetjournals.org/content/154/1/176.abstract
AB The absorption, distribution and metabolism of dimethylsulfoxide (DMSO) have been studied in several animal species using S35-tagged material. Absorption is rapid and complete in the rat and rabbit when administered either orally or dermally. Radioactivity is found in relatively equal concentrations in all tissues soon after dosing, including the ocular tissues. The rat excretes a major part of the dose in the urine within 24 hr, partly as dimethylsulfone, but chiefly as unchanged DMSO. Excretion of label in the rabbit is more prolonged. Metabolism to the sulfone was also demonstrated in the rabbit and guinea pig. © 1966 by The Williams & Wilkins Company