PT  - JOURNAL ARTICLE
AU  - M. L. Graeme
AU  - E. Fabry
AU  - E. B. Sigg
TI  - MYCOBACTERIAL ADJUVANT PERIARTHRITIS IN RODENTS AND ITS MODIFICATION BY ANTIINFLAMMATORY AGENTS
DP  - 1966 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 373--380
VI  - 153
IP  - 2
4099  - http://jpet.aspetjournals.org/content/153/2/373.short
4100  - http://jpet.aspetjournals.org/content/153/2/373.full
SO  - J Pharmacol Exp Ther1966 Aug 01; 153
AB  - Adjuvant periarthritis induced by subplantan injection of Mycobacterium tuberculosis was investigated in rats, mice and guinea pigs. Rats developed disseminated lesions in all extremities, ears and skin, whereas in mice and guinea pigs the inflammation remained localized in the adjuvant-injected paw. Among the various agents administered daily for 14 consecutive days, paramethasone, phenylbutazone, oxyphenbutazone, indomethacin and N-(2,6-dichloro-m-tolyl)-anthranilic acid inhibited full development of inflammation in the adjuvant-injected paw and also reduced lesions in the ears and tail and other extremities. Estradiol, 6-mercaptopunine and amethopterin completely suppressed the disseminated lesions. Chionoquin exerted no significant effect on the acute primary inflammation and the later occurring secondary lesions. Chiorpromazine and streptomycin aggravated the symptoms of adjuvant periarthritis. A second treatment period (days 26 through 35), using paramethasone, phenylbutazone and acetylsalicylic acid, again resulted in arrest and amelionation of the inflammatory process and, in addition, prevented to a great extent the aggravation of inflammation observed after termination of the first treatment. The Williams & Wilkins Comapny