PT  - JOURNAL ARTICLE
AU  - Harry D. Lennon
TI  - RELATIVE EFFECTS OF 17α-ALKYLATED ANABOLIC STEROIDS ON SULFOBROMOPHTHALEIN (BSP) RETENTION IN RABBITS
DP  - 1966 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 143--150
VI  - 151
IP  - 1
4099  - http://jpet.aspetjournals.org/content/151/1/143.short
4100  - http://jpet.aspetjournals.org/content/151/1/143.full
SO  - J Pharmacol Exp Ther1966 Jan 01; 151
AB  - Measurement of sulfobromophthalein (BSP) retention in rabbits was shown to be a simple laboratory test for estimating the effects of anabolic steroids on hepatic excretory function. Non-17α-alkylated androgen-anabolic steroids failed to alter serum BSP levels, whereas 17α-alkylated anabolic steroids caused increased BSP retention when these steroids were given orally to rabbits at 10 and 20 mg/kg of body weight daily for 4 days. The magnitude of effects on BSP retention in the rabbit varied among the various l7α-alkylated steroids and did not appear to be related to myotrophic or androgenic activities, although some correlation was apparent with nitrogen-retaining activity in rats. Several published clinical reports indicated that the relative effects of 17α-alkylated anabolic steroids on BSP retention in human patients were similar to those effects observed in rabbits. The Williams & Wilkins Comapny