PT  - JOURNAL ARTICLE
AU  - Eble, John Nelson
TI  - A PROPOSED MECHANISM FOR THE DEPRESSOR EFFECT OF DOPAMINE IN THE ANESTHETIZED DOG
DP  - 1964 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 64--70
VI  - 145
IP  - 1
4099  - http://jpet.aspetjournals.org/content/145/1/64.short
4100  - http://jpet.aspetjournals.org/content/145/1/64.full
SO  - J Pharmacol Exp Ther1964 Jul 01; 145
AB  - The effect of intravenous dopamine on systemic blood pressure in the anesthetized dog was shown to be the result of a balance between vasoconstriction in some beds (carotid and femoral) and vasodilation in others (superior mesenteric, renal, and celiac). Cardiac output was not muchaffected, but tended to be increased. The systemic depressor effect was usually unaffected or reduced, rarely blocked, by nethalide and the same was found for the dilator effect in the mesentery. The systemic pressor effect of dopamine was reversed by tolazoline, as was the constrictor effect in the separate beds. The Williams & Wilkins Comapny