TY - JOUR T1 - THE FATE OF C<sup>14</sup>-HISTAMINE IN ANIMAL TISSUES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 373 LP - 379 VL - 144 IS - 3 AU - Solomon H. Snyder AU - Julius Axelord AU - Hugo Bauer Y1 - 1964/06/01 UR - http://jpet.aspetjournals.org/content/144/3/373.abstract N2 - Specific methods for the estimation of C14-histamine and its metabolites, methylhistamine, imidazoleacetic acid, and imidazoleacetic acid riboside are described. Circulating histamine is rapidly metabolized in the intact mouse, but small amounts of histamine persist after 48 hours. Methylhistamine is quickly formed and after 30 minutes is present in higher concentrations than histamine. The major metabolic products which are formed and retained in both rat and mouse tissues are imidazoleacetic acid and its riboside. Histamine is unequally distributed among tissues of the mouse and rat. After 24 hours, the rat spleen contains more histamine than any other tissue. The Williams &amp; Wilkins Company ER -