RT Journal Article
SR Electronic
T1 POSSIBLE SITES OF ACTION OF THE RESPIRATORY STIMULANT EFFECT OF DOXAPRAM HYDROCHLORIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 260
OP 264
VO 144
IS 2
A1 Kato, Hitoshi
A1 Buckley, Joseph P.
YR 1964
UL http://jpet.aspetjournals.org/content/144/2/260.abstract
AB Doxapram hydrochloride, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate, has been shown to be a potent respiratory stimulant acting mainly through direct stimulation of central respiratory centers. Data have been presented which indicate that the compound produces a mild stimulation of carotid chemoreceptors. The compound also produces a peripheral stimulating effect due to stimulation of the aortic chemoreceptors and possibly other peripheral chemoreceptors. Doxapram also produced pressor responses through both central and peripheral mechanisms. The Williams & Wilkins Company