PT  - JOURNAL ARTICLE
AU  - Kato, Hitoshi
AU  - Buckley, Joseph P.
TI  - POSSIBLE SITES OF ACTION OF THE RESPIRATORY STIMULANT EFFECT OF DOXAPRAM HYDROCHLORIDE
DP  - 1964 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 260--264
VI  - 144
IP  - 2
4099  - http://jpet.aspetjournals.org/content/144/2/260.short
4100  - http://jpet.aspetjournals.org/content/144/2/260.full
SO  - J Pharmacol Exp Ther1964 May 01; 144
AB  - Doxapram hydrochloride, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate, has been shown to be a potent respiratory stimulant acting mainly through direct stimulation of central respiratory centers. Data have been presented which indicate that the compound produces a mild stimulation of carotid chemoreceptors. The compound also produces a peripheral stimulating effect due to stimulation of the aortic chemoreceptors and possibly other peripheral chemoreceptors. Doxapram also produced pressor responses through both central and peripheral mechanisms. The Williams & Wilkins Company