RT Journal Article
SR Electronic
T1 VASOPRESSOR ACTIVITY OF CYCLOALKANE CARBONYLCHOLINES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 214
OP 217
VO 144
IS 2
A1 Coleman, M. K.
A1 Holland, W. C.
YR 1964
UL http://jpet.aspetjournals.org/content/144/2/214.abstract
AB The vasopressor effects of several cycloalkane carbonylcholines have been examined in the dog. The order of activity was as follows: cyclopropane carbonylcholine > cyclobutane carbonylcholine > cyclopentane carbonylcholine > cyclohexane carbonylcholine. The pressor activity of these substances was compared with that of the corresponding saturated and unsaturated alkyl acid esters of choline. It would appear from the analysis that the cyclopropyl and cyclobutyl ring systems are equivalent to a double bond in the β,β position in the acyl side chain of aliphatic acid esters of choline. Physical evidence in favor of this view is discussed. These findings lend further support to the thesis that the formal negative charge density on the carbonyl oxygen is one important factor determining the intensity of the pressor activity of cholinesters. The Williams & Wilkins Company